Platelet Rich Fibrin

Use of an Autologous Leukocyte and Platelet-Rich Fibrin (L-PRF) Membrane in Post-Avulsion Sites: 

An Overview of Choukroun PRF

Marco Del Corso, DDS, DIU(1), Michal Toffler, DDS(2), David M. Dohan Ehrenfest, DDS, MS, PhD(3)

Choukroun Platelet-Rich Fibrin (PRF) can be considered an autologous healing biomaterial, incorporating leucocytes, platelets and a wide range of key healing proteins within a dense fibrin matrix. With its strong fibrin architecture and slow release of growth factors and glycoproteins over several days, this natural bioactive membrane can enhance soft/hard tissues healing while protecting both surgical sites and grafted materials from external aggression’s. In this article we propose an overview of the use of PRF in post-avulsion sockets or defects. PRF can be used as a filling material in avulsion (or extraction) sockets alone or mixed with a bone substitute. Used as a covering membrane for guided bone regeneration (GBR), PRF both protects the grafted material and accelerates wound closure, particularly when contiguous suture of the wound margins is not possible. The range of clinical applications of PRF is wide, but an accurate knowledge of biomaterial, its biology, efficiency and limits is necessary to optimize its systematic use in daily practice.